Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Bone mass is influenced by genetic and environmental factors. Recent studies have highlighted associations between maternal nutritional status during pregnancy and bone mass in the offspring. We hypothesized that maternal calcium intakes and circulating micronutrients during pregnancy are related to bone mass in Indian children. DESIGN/SETTING/PARTICIPANTS/MAIN OUTCOME MEASURES: Nutritional status was measured at 18 and 28 wk gestation in 797 pregnant rural Indian women. Measurements included anthropometry, dietary intakes (24-h recall and food frequency questionnaire), physical workload (questionnaire), and circulating micronutrients (red cell folate and plasma ferritin, vitamin B12, and vitamin C). Six years postnatally, total body and total spine bone mineral content and bone mineral density (BMD) were measured using dual-energy x-ray absorptiometry (DXA) in the children (n = 698 of 762 live births) and both parents.Both parents' DXA measurements were positively correlated with the equivalent measurements in the children (P < 0.001 for all). The strength of these correlations was similar for fathers and mothers. Children of mothers who had a higher frequency of intake of calcium-rich foods during pregnancy (milk, milk products, pulses, non-vegetarian foods, green leafy vegetables, fruit) had higher total and spine bone mineral content and BMD, and children of mothers with higher folate status at 28 wk gestation had higher total and spine BMD, independent of parental size and DXA measurements.Modifiable maternal nutritional factors may influence bone health in the offspring. Fathers play a role in determining their child's bone mass, possibly through genetic mechanisms or through shared environment.

Original publication

DOI

10.1210/jc.2005-2431

Type

Journal article

Journal

The Journal of clinical endocrinology and metabolism

Publication Date

08/2006

Volume

91

Pages

2994 - 3001

Addresses

Diabetes Unit, Banoo Coyaji Building, KEM Hospital and Research Centre, Rasta Peth, Pune 4110011, Maharashtra, India. diabetes@vsnl.com

Keywords

Humans, Fruit, Vegetables, Prenatal Exposure Delayed Effects, Birth Weight, Calcium, Dietary, Folic Acid, Absorptiometry, Photon, Diet, Nutritional Status, Gestational Age, Pregnancy, Bone Density, Dairy Products, Child, Diet Records, India, Female, Male, Maternal Nutritional Physiological Phenomena, Surveys and Questionnaires