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Diet restriction is a well-recognised method of slowing aging and prolonging life span in animals. However, previous studies of this have tended to start after weaning and the effects of prenatal or early postnatal diet restriction have rarely been considered. Here we summarise the existing literature, which suggests that reducing nutrition at this earlier stage of life has opposite effects, resulting in accelerated aging and a reduction in life span. These findings support emerging epidemiological evidence in man that poor nutrition in early life may programme accelerated aging and predispose to a variety of age-related diseases.

Type

Journal article

Journal

Gerontology

Publication Date

01/1997

Volume

43

Pages

203 - 205

Addresses

MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK. a.p.aihie@soton.ac.uk

Keywords

Animals, Humans, Nutrition Disorders, Disease, Life Expectancy, Nutritional Status, Aging, Child, Preschool, Infant, Infant, Newborn, Infant Nutritional Physiological Phenomena