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Insulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits. This study assessed associations of insulin resistance with health-related quality of life (HRQoL) in different domains of physical and mental health in a large elderly population study. Cross-sectional data of 1212 participants from the Hertfordshire Cohort Study were analysed. Insulin resistance was assessed by the homeostatic model assessment (HOMA-IR), and HRQoL was measured using the SF-36 health survey. Poor HRQoL was defined by a score lower than the sex-specific 10th percentile of each scale, and logistic regressions yielded odds ratios in relation to the HOMA-IR scores. Subsequent analyses adjusted for the influence of age, smoking, alcohol consumption, social class, BMI, coronary heart disease and depression. Results showed an increase in poor HRQoL with an increase in HOMA-IR scores for physical functioning (OR = 2.29; CI: 1.67-3.13), vitality (OR = 1.45; CI: 1.05-2.00), and general health (OR = 1.62; CI: 1.19-2.21). In men, but not in women, associations with physical functioning were independent of confounding variables. The results indicate that insulin resistance is associated with poor HRQoL in domains of physical health, but not in domains of mental health.

Original publication

DOI

10.1007/s11136-006-9129-5

Type

Journal article

Journal

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

Publication Date

04/2007

Volume

16

Pages

429 - 436

Addresses

MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK. ws@mrc.soton.ac.uk

Keywords

Hertfordshire Cohort Study Group, Humans, Diabetes Mellitus, Type 2, Insulin Resistance, Sickness Impact Profile, Risk Factors, Cross-Sectional Studies, Depression, Life Style, Mental Health, Health Status, Quality of Life, Social Class, Aged, Middle Aged, England, Female, Male, Surveys and Questionnaires