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TSG-6 (the product of tumor necrosis factor [TNF]-stimulated gene 6) has a potent inhibitory effect on RANKL-mediated bone erosion. The aim of this study was to compare the activity of TSG-6 with that of osteoprotegerin (OPG) and to investigate its role as an autocrine modulator of cytokine-mediated osteoclast formation/activation. We also determined TSG-6 expression in inflammatory joint disease.

Original publication

DOI

10.1002/art.30201

Type

Journal article

Journal

Arthritis Rheum

Publication Date

04/2011

Volume

63

Pages

1034 - 1043

Addresses

University of Oxford, Oxford, UK.