End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.
Cui L., Rashdan NA., Zhu D., Milne EM., Ajuh P., Milne G., Helfrich MH., Lim K., Prasad S., Lerman DA., Vesey AT., Dweck MR., Jenkins WS., Newby DE., Farquharson C., Macrae VE.
Patients with end-stage renal disease (ESRD) have elevated circulating calcium (Ca) and phosphate (Pi), and exhibit accelerated progression of calcific aortic valve disease (CAVD). We hypothesized that matrix vesicles (MVs) initiate the calcification process in CAVD. Ca induced rat valve interstitial cells (VICs) calcification at 4.5 mM (16.4-fold; p