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Patients with end-stage renal disease (ESRD) have elevated circulating calcium (Ca) and phosphate (Pi), and exhibit accelerated progression of calcific aortic valve disease (CAVD). We hypothesized that matrix vesicles (MVs) initiate the calcification process in CAVD. Ca induced rat valve interstitial cells (VICs) calcification at 4.5 mM (16.4-fold; p 

Original publication




Journal article


J cell physiol

Publication Date





2985 - 2995


Annexin VI, calcific aortic valve disease, calcification, matrix vesicles, Aged, Alkaline Phosphatase, Animals, Annexin A6, Aortic Valve, Aortic Valve Stenosis, Calcinosis, Calcium, Cells, Cultured, Core Binding Factor Alpha 1 Subunit, Extracellular Matrix, Extracellular Vesicles, Female, Homeodomain Proteins, Humans, Hypercalcemia, Kidney Failure, Chronic, Male, Microscopy, Electron, Transmission, Protein Interaction Maps, Proteomics, RNA, Messenger, Rats, Sprague-Dawley, Up-Regulation