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Upregulation of vascular B(1) kinin receptor expression has been reported in human atheroma, but its role remains unclear. We examined vasomotor and fibrinolytic responses to selective B(1) and B(2) kinin receptor agonism in the human femoral circulation and correlated responses with femoral arterial plaque load. Femoral arterial cross-sectional area, blood flow and plaque volume were determined using intravascular ultrasound and Doppler during selective arterial infusion of Lys-des-Arg(9)-bradykinin (B(1) agonist), bradykinin (B(2) agonist) and sodium nitroprusside in eleven patients undergoing diagnostic coronary angiography. Net release of tissue plasminogen activator was determined across the femoral vascular bed. Mean femoral arterial plaque load was 8.1 (±0.9) mm(3)/mm of vessel. Bradykinin and sodium nitroprusside caused dose-dependent increases in femoral blood flow (p 

Original publication




Journal article


Heart vessels

Publication Date





179 - 185


Adult, Aged, Analysis of Variance, Angiotensin-Converting Enzyme Inhibitors, Atherosclerosis, Blood Flow Velocity, Bradykinin, Dose-Response Relationship, Drug, Female, Femoral Artery, Fibrinolysis, Humans, Infusions, Intra-Arterial, Kallidin, Lower Extremity, Male, Middle Aged, Nitroprusside, Receptor, Bradykinin B1, Receptor, Bradykinin B2, Regional Blood Flow, Scotland, Tissue Plasminogen Activator, Ultrasonography, Doppler, Ultrasonography, Interventional, Vasodilation, Vasodilator Agents, Vasomotor System