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Calcific aortic stenosis is the commonest adult valvular heart condition seen in the western world. Its prevalence is continuing to rise, with predominance in older patients who are frequently undergoing successful aortic valve replacement. This review discusses the natural history of calcific aortic stenosis, highlights recent insights into its pathogenesis, and outlines current medical and surgical management. The potential role of novel therapeutic interventional strategies is discussed.

Original publication




Journal article


Age ageing

Publication Date





538 - 544


Age Factors, Aged, Aged, 80 and over, Aortic Valve, Aortic Valve Stenosis, Arteriosclerosis, Calcinosis, Catheterization, Diagnosis, Differential, Disease Progression, Heart Valve Prosthesis Implantation, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Inflammation, Risk Factors