Pathogenesis of psoriasis and psoriatic arthritis
Coates L., Savage L., Emery P.
The pathophysiology of psoriasis is multifaceted and dynamic, involving a complex interplay between constitutive cells of the skin and the innate and adaptive immune systems. Until the early 1980s, psoriasis was considered to be primarily a disease of epidermal keratinocyte proliferation, with the cutaneous inflammatory infiltrate a secondary consequence.