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A breakdown in intestinal homeostasis can result in chronic inflammatory diseases of the gut including inflammatory bowel disease, coeliac disease and allergy. Dendritic cells, through their ability to orchestrate protective immunity and immune tolerance in the host, have a key role in shaping the intestinal immune response. The mechanisms through which dendritic cells can respond to environmental cues in the intestine and select appropriate immune responses have until recently been poorly understood. Here, we review recent work that is beginning to identify factors responsible for intestinal conditioning of dendritic-cell function and the subsequent decision between tolerance and immunity in the intestine.

Original publication

DOI

10.1038/nri2335

Type

Journal article

Journal

Nature reviews. Immunology

Publication Date

06/2008

Volume

8

Pages

435 - 446

Addresses

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.

Keywords

Intestines, Dendritic Cells, Animals, Humans, Immunophenotyping, Immune Tolerance, Immunity, Cellular