Association of COVID-19 With Risk of Posttransplant Diabetes Mellitus
Vinson AJ., Anzalone AJ., Schissel M., Dai R., Olex AL., Mannon RB., Wilcox AB., Lee AM., Graves A., Manna A., Saha A., Zhou A., Williams AE., Southerland A., Girvin AT., Walden A., Sharathkumar AA., Amor B., Bates B., Hendricks B., Patel B., Alexander C., Bramante C., Ward-Caviness C., Madlock-Brown C., Suver C., Chute C., Dillon C., Wu C., Schmitt C., Takemoto C., Housman D., Gabriel D., Eichmann DA., Mazzotti D., Brown D., Boudreau E., Hill E., Zampino E., Carlson Marti E., Pfaff ER., French E., Koraishy FM., Mariona F., Prior F., Agarwal G., Sokos G., Martin G., Lehmann H., Spratt H., Mehta H., Liu H., Sidky H., Awori Hayanga JW., Pincavitch J., Clark J., Richard Harper J., Islam J., Ge J., Gagnier J., Saltz JH., Saltz J., Loomba J., Buse J., Mathew J., Rutter JL., Mcmurry JA., Guinney J., Starren J., Crowley K., Rebecca Bradwell K., Walters KM., Wilkins K., Gersing KR., Dwain Cato K., Murray K., Kostka K., Northington L., Allan Pyles L., Misquitta L., Cottrell L., Portilla L., Deacy M., Bissell MM., Clark M., Emmett M., Morrison Saltz M., Palchuk MB., Haendel MA., Adams M., Temple-O'connor M., Kurilla MG., Morris M., Qureshi N., Safdar N., Garbarini N., Sharafeldin N., Sadan O., Francis PA., Wung Burgoon P.
Background. Posttransplant diabetes mellitus (PTDM) is an important complication for solid organ transplant recipients (SOTRs). COVID-19 has been associated with an increased risk of incident diabetes in the general population. However, the association between COVID-19 and new-onset PTDM has not been explored. Methods. Using the National COVID Cohort Collaborative Enclave, we conducted a cohort study of adults without diabetes receiving a solid organ transplant (heart, lung, kidney, or liver) in the United States between April 1, 2020, and March 31, 2023, with and without a first diagnosis of COVID-19 (COVID+ versus COVID-) within 180 d of SOT. We propensity score matched a single COVID+ SOTR with a COVID- SOTR who was diabetes free at the same point posttransplant. Within this matched cohort, we used multivariable Cox proportional hazards models to examine the adjusted risk of PTDM associated with COVID+. Results. Among 1342 COVID+ SOTRs matched to 1342 COVID- SOTRs, the crude rate of newly diagnosed PTDM in the 2 y post-COVID was 17% in those with versus 13% in those without COVID-19 (P = 0.007). COVID-19 was significantly associated with new PTDM (adjusted hazard ratio, 1.37; 95% confidence interval, 1.12-1.68 at 2 y). Conclusions. Similar to other viral infections, COVID-19 is associated with an increased risk of PTDM in SOTRs.