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The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made.

Original publication

DOI

10.1016/j.berh.2003.09.010

Type

Journal article

Journal

Best practice & research. Clinical rheumatology

Publication Date

02/2004

Volume

18

Pages

59 - 80

Addresses

Kennedy Institute of Rheumatology Division, Imperial College, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK. m.feldmann@imperial.ac.uk

Keywords

Synovial Membrane, Animals, Humans, Mice, Arthritis, Rheumatoid, Disease Models, Animal, Tumor Necrosis Factor-alpha, RNA, Messenger, Antirheumatic Agents, Autoantibodies, Cytokines, Sensitivity and Specificity, Research Design, Clinical Trials as Topic