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A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.

Original publication

DOI

10.1021/ja038025w

Type

Journal article

Journal

Journal of the American Chemical Society

Publication Date

12/2003

Volume

125

Pages

15700 - 15701

Addresses

Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Keywords

Animals, Porifera, Alkaloids, Pyrroles, Angiogenesis Inhibitors, Enzyme Inhibitors, Nuclear Magnetic Resonance, Biomolecular, Spectrometry, Mass, Fast Atom Bombardment, Matrix Metalloproteinase Inhibitors