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Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between platelets and thrombogenic elements within the atherosclerotic lesions. Considering the socioeconomic burden of ACS, it is imperative that the scientific community achieves a clear understanding of the multifaceted pathophysiology of vulnerable atheroma to identify accurate prognostic biomarkers and therapeutic targets. The analytical power of modern proteomic technologies could facilitate our understanding of vulnerable plaques and lead to the discovery of novel therapeutic targets and diagnostic biomarkers.

Type

Journal

Current atherosclerosis reports

Publication Date

05/2009

Volume

11

Pages

188 - 195

Addresses

Cardiovascular Division, The James Black Centre, King's College London School of Medicine, King's College London, 125 Coldharbour Lane, London SE59NU, United Kingdom.

Keywords

Humans, Coronary Thrombosis, Proteomics, Acute Coronary Syndrome