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The immune system has evolved to eliminate or inactivate infectious organisms. An inappropriate response against self-components (autoantigens) can result in autoimmune disease. Here we examine the hypothesis that some evolutionarily conserved proteins, present in pathogenic and commensal organisms and their hosts, provide the stimulus that initiates autoimmune disease in susceptible individuals. We focus on seven autoantigens, of which at least four, glutamate decarboxylase, pyruvate dehydrogenase, histidyl-tRNA synthetase and alpha enolase, have orthologs in bacteria. Citrullinated alpha-enolase, a target for autoantibodies in 40% of patients with rheumatoid arthritis, is our main example. The major epitope is highly conserved, with over 90% identity to human in some bacteria. We propose that this reactivity of autoantibodies to shared sequences provides a model of autoimmunity in rheumatoid arthritis, which may well extend to other autoimmune disease in humans.

Original publication

DOI

10.1016/j.biocel.2008.09.012

Type

Journal article

Journal

The international journal of biochemistry & cell biology

Publication Date

02/2009

Volume

41

Pages

390 - 397

Addresses

Kennedy Institute of Rheumatology Division, Imperial College London, 65 Aspenlea Road, London W6 8LH, UK.

Keywords

Animals, Humans, Bacteria, Autoimmune Diseases, Antigens, Bacterial, Autoantigens, Immunodominant Epitopes, Evolution, Molecular, Molecular Mimicry, Amino Acid Sequence, Conserved Sequence, Molecular Sequence Data