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CD4(+)CD25(+) regulatory T cells have been shown to prevent T cell-mediated immune pathology; however, their ability to ameliorate established inflammation has not been tested. Using the CD4(+)CD45RB(high) T cell transfer model of inflammatory bowel disease, we show that CD4(+)CD25(+) but not CD4(+)CD25(-)CD45RB(low) T cells are able to cure intestinal inflammation. Transfer of CD4(+)CD25(+) T cells into mice with colitis led to resolution of the lamina propria infiltrate in the intestine and reappearance of normal intestinal architecture. CD4(+)CD25(+) T cells were found to proliferate in the mesenteric lymph nodes and inflamed colon. They were located between clusters of CD11c(+) cells and pathogenic T cells and found to be in contact with both cell types. These studies suggest that manipulation of CD4(+)CD25(+) T cells may be beneficial in the treatment of chronic inflammatory diseases.

Original publication




Journal article


Journal of immunology (Baltimore, Md. : 1950)

Publication Date





3939 - 3943


Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.


Mesentery, Colon, Lymph Nodes, T-Lymphocyte Subsets, CD4-Positive T-Lymphocytes, Animals, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Mice, Mice, SCID, Colitis, Wasting Syndrome, Antigens, CD11c, Receptors, Interleukin-2, Adoptive Transfer, Cell Communication, Cell Division, Cell Movement