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The growth and metastasis of solid tumors not only depends on their ability to escape from immune surveillance but also hinges on their ability to invade the vasculature system as well as to induce the formation of new blood vessels. Gr-1(+)CD11b(+) myeloid-derived suppressor cells (MDSCs), overproduced in tumor-bearing hosts, contribute significantly to all these aspects. They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis.

Original publication

DOI

10.1002/jbmr.154

Type

Journal article

Journal

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Publication Date

08/2010

Volume

25

Pages

1701 - 1706

Addresses

Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA.

Keywords

Myeloid Cells, Animals, Humans, Bone Neoplasms, Neoplasm Metastasis, Inflammation, Receptors, Chemokine, Antigens, CD11b