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Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive cancer) by 15.2% (SE 1.6%, 12.9% vs 28.1% 2 P

Original publication




Journal article


J natl cancer inst monogr

Publication Date





162 - 177


Adult, Aged, Antineoplastic Agents, Hormonal, Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Intraductal, Noninfiltrating, Chemotherapy, Adjuvant, Combined Modality Therapy, Female, Humans, Mastectomy, Segmental, Meta-Analysis as Topic, Middle Aged, Multicenter Studies as Topic, Neoplasm Recurrence, Local, Neoplasms, Second Primary, Radiotherapy, Adjuvant, Randomized Controlled Trials as Topic, Tamoxifen