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Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2rgamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2rgamma(-/-)Rag2(-/-) LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR(+) T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.

Original publication

DOI

10.1073/pnas.0604183103

Type

Journal article

Journal

Proceedings of the national academy of sciences of the united states of america

Publication Date

09/2006

Volume

103

Pages

13457 - 13462

Addresses

Division of Molecular Immunology and Immune Cell Biology and Confocal Microscopy and Image Analysis Laboratory, National Institute for Medical Research, Mill Hill, London, United Kingdom. m542@york.ac.uk

Keywords

Lymph Nodes, Killer Cells, Natural, T-Lymphocytes, Animals, Animals, Newborn, Mice, Knockout, Mice, Mice, Mutant Strains, NF-kappa B, Green Fluorescent Proteins, Receptors, Interleukin-7, DNA, Complementary, Interleukin-7, Adoptive Transfer, Mutation, Transgenes, Models, Biological