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Parkinson's disease (PD) is characterised by the death of dopaminergic neurons of the substantia nigra. As Nurr1 seems to regulate the development and maintenance of these neurons, we evaluated its potential role in Parkinson's disease using genetic methods. We genotyped two polymorphisms and screened a case-control sample for the presence/absence of two mutations recently described in exon 1. Our results failed to replicate the association initially observed and none of the mutations were present in our familial Parkinson's disease cases. These observations suggest that this gene is unlikely to play a major effect in French familial Parkinson disease.

Original publication

DOI

10.1016/j.neulet.2004.05.028

Type

Journal article

Journal

Neurosci lett

Publication Date

12/08/2004

Volume

366

Pages

135 - 138

Keywords

Aged, Case-Control Studies, DNA-Binding Proteins, Genotype, Humans, Middle Aged, Mutation, Nuclear Receptor Subfamily 4, Group A, Member 2, Parkinsonian Disorders, Pedigree, Polymorphism, Genetic, Transcription Factors