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To measure reproducibility, longitudinal and cross-sectional differences in T2* maps at 3 Tesla (T) in the articular cartilage of the knee in subjects with osteoarthritis (OA) and healthy matched controls.MRI data and standing radiographs were acquired from 33 subjects with OA and 21 healthy controls matched for age and gender. Reproducibility was determined by two sessions in the same day, while longitudinal and cross-sectional group differences used visits at baseline, 3 and 6 months. Each visit contained symptomological assessments and an MRI session consisting of high resolution three-dimensional double-echo-steady-state (DESS) and co-registered T2* maps of the most diseased knee. A blinded reader delineated the articular cartilage on the DESS images and median T2* values were reported.T2* values showed an intra-visit reproducibility of 2.0% over the whole cartilage. No longitudinal effects were measured in either group over 6 months. T2* maps revealed a 5.8% longer T2* in the medial tibial cartilage and 7.6% and 6.5% shorter T2* in the patellar and lateral tibial cartilage, respectively, in OA subjects versus controls (P < 0.02).T2* mapping is a repeatable process that showed differences between the OA subject and control groups.

Original publication

DOI

10.1002/jmri.23598

Type

Journal article

Journal

Journal of magnetic resonance imaging : JMRI

Publication Date

06/2012

Volume

35

Pages

1422 - 1429

Addresses

GSK Clinical Imaging Centre, Hammersmith Hospital, Imperial College London, London, United Kingdom. rexford.newbould@gmail.com

Keywords

Cartilage, Articular, Knee Joint, Humans, Osteoarthritis, Knee, Magnetic Resonance Imaging, Sensitivity and Specificity, Reproducibility of Results, Middle Aged, Female, Male