Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

T cell antigen recognition is accompanied by cytoskeletal polarization towards the APC and large-scale redistribution of cell surface molecules into 'supramolecular activation clusters' (SMACs), forming an organized contact interface termed the 'immunological synapse' (IS). Molecules are arranged in the IS in a micrometer scale bull's eye pattern with a central accumulation of TCR/peptide-MHC (the cSMAC) surrounded by a peripheral ring of adhesion molecules (the pSMAC). We propose that segregation of cell surface molecules on a much smaller scale initiates TCR triggering, which drives the formation of the IS by active transport processes. IS formation may function as a checkpoint for full T cell activation, integrating information on the presence and quality of TCR ligands and the nature and activation state of the APC.

Type

Journal article

Journal

Seminars in immunology

Publication Date

02/2000

Volume

12

Pages

5 - 21

Addresses

Sir William Dunn School of Pathology, University of Oxford, UK.

Keywords

Antigen-Presenting Cells, T-Lymphocytes, Animals, Humans, Cytoskeletal Proteins, Receptors, Antigen, T-Cell, Antigens, Surface, Signal Transduction