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During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 × 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 × 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 × 10(-3) for 6q22 and 1.2 × 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.

Type

Journal article

Journal

Nature genetics

Publication Date

05/2012

Volume

44

Pages

539 - 544

Addresses

Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands. m.a.ikram@erasmusmc.nl

Keywords

Early Growth Genetics Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Head, Brain, Chromosomes, Human, Pair 6, Chromosomes, Human, Pair 17, Humans, Genetic Markers, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Infant, Female, Male, Genome-Wide Association Study, Genetic Loci