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Stage and age at diagnosis are important prognostic factors for patients with colorectal cancer. However, the proportion cured by stage and age is unknown in England.This population-based study includes 29,563 adult patients who were diagnosed and registered with colorectal cancer during 1997-2004 and followed till 2007 in North West England. Multiple imputation was used to provide more reliable estimates of stage at diagnosis, when these data were missing. Cure mixture models were used to estimate the proportion 'cured' and the median survival of the uncured by age and stage.For both colon and rectal cancer the proportion of patients cured and median survival time of the uncured decreased with advancing stage and increasing age. Patients aged under 65 years had the highest proportion cured and longest median survival of the uncured.Cure of colorectal cancer patients is dependent on stage and age at diagnosis with younger patients or those with less advanced disease having a better prognosis. Further efforts are required, in order to reduce the proportion of patients presenting with stage III and IV disease and ultimately increase the chance of cure.

Original publication

DOI

10.1016/j.canep.2012.06.011

Type

Journal article

Journal

Cancer epidemiology

Publication Date

12/2012

Volume

36

Pages

548 - 553

Addresses

Preventative Oncology and Community Health Sciences, University of Calgary, Calgary, Canada. lorraine.shack@albertahealthservice.ca

Keywords

Humans, Colorectal Neoplasms, Neoplasm Staging, Prognosis, Registries, Survival Analysis, Age Factors, Age Distribution, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, England, Female, Male, Young Adult