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Maternal thinness leads to metabolic challenges in the offspring, but it is unclear whether reduced maternal fat mass or muscle mass drives these metabolic changes. Recently, it has been shown that low maternal muscle mass--as measured by arm muscle area (AMA)--is associated with depressed nutrient transport to the fetus. To determine the role of maternal muscle mass on placental function, we analyzed the gene expression profiles of 30 human placentas over the range of AMA (25.2-90.8 cm(2)) from uncomplicated term pregnancies from the Southampton Women's Survey cohort. Eighteen percent of the ∼60 genes that were highly expressed in less muscular women were related to immune system processes and the interferon-γ (IFNG) signaling pathway in particular. Those transcripts related to the IFNG pathway included IRF1, IFI27, IFI30, and GBP6. Placentas from women with low muscularity are, perhaps, more sensitive to the effects of inflammatory cytokines than those from more muscular women.

Type

Journal article

Journal

Reproductive sciences (Thousand Oaks, Calif.)

Publication Date

10/2012

Volume

19

Pages

1041 - 1056

Addresses

Heart Research Center, Oregon Health and Science University, Portland, OR, USA.

Keywords

Arm, Muscle, Skeletal, Placenta, Humans, Thinness, Membrane Proteins, Organ Size, Cohort Studies, Signal Transduction, Immunity, Pregnancy, Female, Male, Interferon Regulatory Factor-1, Oxidoreductases Acting on Sulfur Group Donors, Interferon-gamma, Transcriptome