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Giant cell tumors deriving from synovium are classified into a localized (GCT of tendon sheath; GCT-TS) and diffuse form (diffuse-type GCT, Dt-GCT). We propose a multidisciplinary management based upon a systematic review and authors' opinion. Open excision for GCT-TS and open synovectomy (plus excision) for Dt-GCT is advised to reduce the relatively high recurrence risk. External beam radiotherapy should be considered in severe cases, as Dt-GCT commonly extends extra-articular.

Original publication

DOI

10.1002/jso.23220

Type

Journal article

Journal

Journal of surgical oncology

Publication Date

03/2013

Volume

107

Pages

433 - 445

Addresses

Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands. l.van_der_heijden@lumc.nl

Keywords

Synovial Membrane, Tendons, Humans, Giant Cell Tumors, Neoplasm Recurrence, Local, Tenosynovitis, Radioisotopes, Benzamides, Piperazines, Pyrimidines, Pyrroles, Indoles, Antineoplastic Agents, Protein Kinase Inhibitors, Magnetic Resonance Imaging, Arthroscopy, Chemotherapy, Adjuvant, Radiotherapy, Adjuvant, Arthroplasty, Interdisciplinary Communication, Adult, Middle Aged, Female, Male, Protein-Tyrosine Kinases, Molecular Targeted Therapy, Imatinib Mesylate