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Giant cell tumors deriving from synovium are classified into a localized (GCT of tendon sheath; GCT-TS) and diffuse form (diffuse-type GCT, Dt-GCT). We propose a multidisciplinary management based upon a systematic review and authors' opinion. Open excision for GCT-TS and open synovectomy (plus excision) for Dt-GCT is advised to reduce the relatively high recurrence risk. External beam radiotherapy should be considered in severe cases, as Dt-GCT commonly extends extra-articular.

Original publication

DOI

10.1002/jso.23220

Type

Journal article

Journal

J Surg Oncol

Publication Date

03/2013

Volume

107

Pages

433 - 445

Keywords

Adult, Antineoplastic Agents, Arthroplasty, Arthroscopy, Benzamides, Chemotherapy, Adjuvant, Female, Giant Cell Tumors, Humans, Imatinib Mesylate, Indoles, Interdisciplinary Communication, Magnetic Resonance Imaging, Male, Middle Aged, Molecular Targeted Therapy, Neoplasm Recurrence, Local, Piperazines, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Pyrimidines, Pyrroles, Radioisotopes, Radiotherapy, Adjuvant, Synovial Membrane, Tendons, Tenosynovitis