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Kidney stones are common, with a multifactorial etiology involving dietary, environmental, and genetic factors. In addition, patients with nephrolithiasis are at greater risk of hypertension, diabetes mellitus, metabolic syndrome, and osteoporosis, although the basis for this is not fully understood. All of these renal stone-associated conditions have also been linked with adverse early-life events, including low-birth weight, and it has been suggested that this developmental effect is due to excess exposure to maternal glucocorticoids in utero. This is proposed to result in long-term increased hypothalamic-pituitary-axis activation; there are mechanisms through which this effect could also promote urinary lithogenic potential. We therefore hypothesize that the association between renal stone disease and hypertension, diabetes mellitus, metabolic syndrome, and osteoporosis may be related by a common pathway of programming in early life, which, if validated, would implicate the developmental origins hypothesis in the etiology of nephrolithiasis.

Original publication

DOI

10.1002/jbmr.1993

Type

Journal article

Journal

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Publication Date

12/2013

Volume

28

Pages

2535 - 2539

Addresses

Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Keywords

Fetus, Humans, Kidney Calculi, Hypertension, Diabetes Mellitus, Type 2, Metabolic Syndrome X, Risk Factors, Fetal Development, Models, Biological