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It is increasingly recognized that cell signaling, as a chemical process, must be considered at the local, micrometer scale. Micro- and nanofabrication techniques provide access to these dimensions, with the potential to capture and manipulate the spatial complexity of intracellular signaling in experimental models. This review focuses on recent advances in adapting surface engineering for use with biomolecular systems that interface with cell signaling, particularly with respect to surfaces that interact with multiple receptor systems on individual cells. The utility of this conceptual and experimental approach is demonstrated in the context of epithelial cells and T lymphocytes, two systems whose ability to perform their physiological function is dramatically impacted by the convergence and balance of multiple signaling pathways.

Original publication

DOI

10.1146/annurev-bioeng-071811-150050

Type

Journal article

Journal

Annual review of biomedical engineering

Publication Date

01/2013

Volume

15

Pages

305 - 326

Addresses

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. lk2141@columbia.edu

Keywords

T-Lymphocytes, Extracellular Matrix, Epithelial Cells, Immune System, Animals, Humans, Biocompatible Materials, Tissue Engineering, Cell Adhesion, Cell Communication, Signal Transduction, Epithelial-Mesenchymal Transition, Spindle Apparatus