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After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived memory CD8+ cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8+ effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8+ T cell immunity.

Original publication

DOI

10.1038/ni.2536

Type

Journal article

Journal

Nature immunology

Publication Date

04/2013

Volume

14

Pages

404 - 412

Addresses

Division of Biological Sciences, University of California San Diego, La Jolla, California, USA.

Keywords

Immunological Genome Project Consortium, CD8-Positive T-Lymphocytes, Animals, Mice, Infection, Receptors, Antigen, T-Cell, Cluster Analysis, Gene Expression Profiling, Computational Biology, Cell Differentiation, Immunologic Memory, Transcription, Genetic, Gene Expression Regulation, Male