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The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is formed.

Original publication

DOI

10.1101/cshperspect.a002311

Type

Journal article

Journal

Cold Spring Harbor perspectives in biology

Publication Date

10/2010

Volume

2

Addresses

Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, New York 10016, USA.

Keywords

T-Lymphocytes, Animals, Humans, Mice, Receptors, Antigen, T-Cell, Lymphocyte Activation, Signal Transduction, Cell Movement, Cell Polarity, Immunological Synapses