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Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-associated molecule (Crtam).

Original publication

DOI

10.1016/j.cell.2008.02.016

Type

Journal article

Journal

Cell

Publication Date

07/03/2008

Volume

132

Pages

733 - 734

Keywords

Animals, Cell Division, Cell Polarity, Humans, Immunoglobulins, Models, Biological, T-Lymphocytes