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We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.

Original publication

DOI

10.1038/ng.717

Type

Journal article

Journal

Nature genetics

Publication Date

12/2010

Volume

42

Pages

1118 - 1125

Addresses

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

Keywords

Humans, Crohn Disease, Genetic Predisposition to Disease, Reproducibility of Results, Computational Biology, Genome, Human, Genetic Variation, Genome-Wide Association Study, Genetic Loci, Genetic Linkage