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The intestine represents one of the most challenging sites for the immune system as immune cells must be able to mount an efficient response to invading pathogens while tolerating the large number and diverse array of resident commensal bacteria. Foxp3(+) regulatory T-cells (Tregs) play a non-redundant role at maintaining this balance. At the same time Treg cell differentiation and function can be modulated by the intestinal microbiota. In this review, we will discuss effector mechanisms of Treg cells in the intestine and how these cells can be influenced by the intestinal microbiota.

Original publication

DOI

10.1016/j.smim.2013.09.002

Type

Journal article

Journal

Seminars in immunology

Publication Date

11/2013

Volume

25

Pages

352 - 357

Addresses

Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

Keywords

Intestines, Thymus Gland, Animals, Humans, Bacteria, Homeostasis, T-Lymphocytes, Regulatory, Microbiota