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Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major histocompatibility complex class II proteins (pMHC) molecules per μm(2). We demonstrate that these substrates induce T cell responses in a pMHC dose-dependent manner and that the number of presented pMHCs dominates over local pMHC density.

Original publication

DOI

10.1021/nl403266t

Type

Journal article

Journal

Nano letters

Publication Date

01/2013

Volume

13

Pages

5619 - 5626

Addresses

Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems , Heisenbergstraße 3, D-70569 Stuttgart, Germany.

Keywords

Synapses, Antigen-Presenting Cells, T-Lymphocytes, Humans, Membrane Proteins, Lymphocyte Activation, Major Histocompatibility Complex, Nanoparticles