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Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus, the relative role of these receptors has not been formally examined. In this paper, we have investigated the contribution of the mannose receptor, Dectin-1, and complement receptor 3; and we have demonstrated that Dectin-1 is the main non-opsonic receptor involved in fungal uptake. However, both Dectin-1 and complement receptor 3 were found to accumulate at the site of uptake, while mannose receptor accumulated on C. albicans phagosomes at later stages. These results suggest a potential role for MR in phagosome sampling; and, accordingly, MR deficiency led to a reduction in TNF-alpha and MCP-1 production in response to C. albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion.

Original publication

DOI

10.1371/journal.ppat.1000218

Type

Journal article

Journal

Plos pathog

Publication Date

11/2008

Volume

4

Keywords

Animals, Candida albicans, Humans, Lectins, C-Type, Macrophage-1 Antigen, Mannose-Binding Lectins, Membrane Proteins, Mice, Nerve Tissue Proteins, Phagocytosis, Phagosomes, Receptors, Cell Surface, Receptors, Pattern Recognition, Time Factors