Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus, the relative role of these receptors has not been formally examined. In this paper, we have investigated the contribution of the mannose receptor, Dectin-1, and complement receptor 3; and we have demonstrated that Dectin-1 is the main non-opsonic receptor involved in fungal uptake. However, both Dectin-1 and complement receptor 3 were found to accumulate at the site of uptake, while mannose receptor accumulated on C. albicans phagosomes at later stages. These results suggest a potential role for MR in phagosome sampling; and, accordingly, MR deficiency led to a reduction in TNF-alpha and MCP-1 production in response to C. albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion.

Original publication

DOI

10.1371/journal.ppat.1000218

Type

Journal article

Journal

PLoS pathogens

Publication Date

28/11/2008

Volume

4

Addresses

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

Keywords

Phagosomes, Animals, Humans, Mice, Candida albicans, Lectins, C-Type, Mannose-Binding Lectins, Membrane Proteins, Receptors, Cell Surface, Macrophage-1 Antigen, Nerve Tissue Proteins, Phagocytosis, Time Factors, Receptors, Pattern Recognition