Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVE: To investigate the possible immunoregulatory role of interleukin-11 (IL-11) in rheumatoid arthritis (RA). METHODS: IL-11 protein was assayed in RA tissue, and the effect of exogenous IL-11 on neutralization of endogenous IL-11 was investigated with respect to tumor necrosis factor alpha (TNFalpha), matrix metalloproteinase (MMP), and tissue inhibitor of metalloproteinases (TIMP) production. RESULTS: IL-11 was found in RA synovial membranes, synovial fluids, and blood sera. Blockade of endogenous IL-11 resulted in a 2-fold increase in TNFalpha levels, which increased to 22-fold if endogenous IL-10 was also blocked. Addition of exogenous IL-11 inhibited spontaneous TNFalpha production in RA synovium only in the presence of soluble IL-11 receptor. However, exogenous IL-11 directly inhibited spontaneous MMP-1 and MMP-3 production, and up-regulated TIMP-1 in RA synovial tissue. CONCLUSION: IL-11 has important endogenous immunoregulatory effects in RA synovium, which suggests that exogenous IL-11 may have therapeutic activity in RA.

Original publication

DOI

10.1002/1529-0131(199808)41:8<1388::aid-art7>3.0.co;2-f

Type

Journal article

Journal

Arthritis and rheumatism

Publication Date

08/1998

Volume

41

Pages

1388 - 1397

Addresses

The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK.

Keywords

Synovial Membrane, Synovial Fluid, Monocytes, Cells, Cultured, Fibroblasts, Humans, Arthritis, Rheumatoid, Metalloendopeptidases, Tumor Necrosis Factor-alpha, Receptors, Interleukin, Recombinant Proteins, Inflammation Mediators, Interleukin-1, Interleukin-10, Interleukin-11, Adjuvants, Immunologic, Cytokines, Enzyme Inhibitors, Drug Interactions, Solubility