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Tumor necrosis factor alpha (TNF alpha) is a cytokine with many biological functions of relevance to inflammatory disease. Although only one of several inflammatory mediators produced in abundance in rheumatoid arthritis (RA), experimental data suggest that it is in a dominant position within a cytokine hierarchy and is therefore a prime target for directed immunotherapy in this disease. We have targeted TNF alpha in vivo using a chimerised monoclonal anti-TNF alpha antibody and have now demonstrated beneficial responses to treatment in three different clinical trials. The results confirm that TNF alpha is of central importance in the inflammatory process in RA and define a new treatment strategy in this disease.

Original publication

DOI

10.1016/0192-0561(94)00092-3

Type

Journal article

Journal

International journal of immunopharmacology

Publication Date

02/1995

Volume

17

Pages

141 - 145

Addresses

Kennedy Institute of Rheumatology, London, U.K.

Keywords

Animals, Humans, Mice, Arthritis, Rheumatoid, Tumor Necrosis Factor-alpha, Acute-Phase Proteins, Recombinant Fusion Proteins, Antibodies, Monoclonal, Cytokines, Treatment Outcome, Female, Male, Clinical Trials as Topic