Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We recently showed that human thyroid epithelial cells, which are normally negative for HLA-DR molecules, express HLA-DR in thyroid autoimmunity. Furthermore, induction of HLA-DR on normal thyroid cells can be achieved by culture with plant lectins. We have now found that recombinant human interferon-gamma (IFN-gamma) induces expression of HLA-DR molecules on cultured human thyroid cells, whereas Namalva IFN-alpha, recombinant IFN-beta or recombinant interleukin-2 (IL-2) do not. All three IFN, but not IL-2, enhanced thyroid cell HLA-A,B,C expression. The results strongly implicate T cells (which are the source of IFN-gamma) in the aberrant induction of DR on thyroid epithelial cells which is proposed to be a central feature of the immunopathological processes leading to autoimmunity.

Type

Journal article

Journal

Clinical and experimental immunology

Publication Date

08/1985

Volume

61

Pages

265 - 273

Keywords

Thyroid Gland, Epithelium, Cells, Cultured, Humans, Interleukin-2, HLA-A Antigens, HLA-B Antigens, HLA-C Antigens, Histocompatibility Antigens Class II, HLA-DR Antigens, HLA Antigens, Fluorescent Antibody Technique, Dose-Response Relationship, Drug, Interferon-gamma