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The presence of neutrophils in the synovial joint of patients with rheumatoid arthritis (RA) is thought to be due to the activity of chemotactic factors released by activated cells in the joint. We have shown in this report, for the first time, the abundance of one such factor, interleukin 8 (IL 8), in the synovial fluid of patients both with RA and other non-RA joint diseases, and the spontaneous production of IL 8 mRNA by RA synovial cells in culture. There was no correlation between the levels of chemotactic activity and IL 8 protein, suggesting that other factors with similar neutrophil chemotactic activity are also present in the synovial fluid exudate. In support of this concept neither the level of chemotactic activity nor IL 8 protein levels correlated with neutrophil or leukocyte infiltration, indicating that the mechanism of migration into the inflammatory environment of the joint is complex. Such migration is likely to be due to a number of chemotactic signals in addition to IL 8, which may either synergize with, or inhibit, the action of IL 8.

Original publication

DOI

10.1002/eji.1830200938

Type

Journal article

Journal

European journal of immunology

Publication Date

09/1990

Volume

20

Pages

2141 - 2144

Addresses

Charing Cross Sunley Research Centre, Hammersmith, London, GB.

Keywords

Synovial Fluid, Neutrophils, Humans, Arthritis, Rheumatoid, Tumor Necrosis Factor-alpha, RNA, Messenger, Interleukin-8, Interleukin-1, Chemotaxis, Leukocyte, Adult, Aged, Middle Aged