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The effect of tumour necrosis factor (TNF alpha) antibodies on synovial cell interleukin-1 (IL-1) production was investigated in 7 patients with rheumatoid arthritis and in 7 with osteoarthritis. Synovial cell IL-1 production was significantly reduced by anti-TNF alpha antibody in cultures from patients with rheumatoid arthritis, but antilymphotoxin antibody did not have this effect (except in 1 culture). In cultures from patients with osteoarthritis spontaneous IL-1 production was low, despite high concentrations of TNF alpha, and IL-1 production was not inhibited by anti-TNF alpha antibody. In rheumatoid arthritis, TNF alpha may be the main inducer of IL-1, and anti-TNF alpha agents may be useful in treatment.

Original publication

DOI

10.1016/s0140-6736(89)90430-3

Type

Journal article

Journal

Lancet (London, England)

Publication Date

07/1989

Volume

2

Pages

244 - 247

Addresses

Charing Cross Sunley Research Centre, Hammersmith, London.

Keywords

Synovial Membrane, Cells, Cultured, Humans, Arthritis, Rheumatoid, Osteoarthritis, Tumor Necrosis Factor-alpha, Interleukin-1, Immune Sera, Antilymphocyte Serum, Enzyme-Linked Immunosorbent Assay, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male