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The ability of immune complexes derived from patients with type II mixed essential cryoglobulinemia to trigger the production of interleukin 1 (IL 1) was investigated. Immune complexes containing either IgM/IgG or IgA/IgG aggregates were shown to induce IL 1 production in human peripheral blood monocyte-enriched populations. Interferon-gamma alone did not induce detectable IL 1, but increased the IL 1 production induced by the immune complexes. Tumor necrosis factor-alpha, which is a potent inducer of IL 1, also enhanced IL 1 production following stimulation with suboptimal doses of the immune complex. The findings suggest that immune complexes may induce inflammation partly due to their capacity to induce the synthesis of IL 1.

Original publication

DOI

10.1002/eji.1830190130

Type

Journal article

Journal

European journal of immunology

Publication Date

01/1989

Volume

19

Pages

189 - 192

Addresses

Charing Cross Sunley Research Centre, London, GB.

Keywords

Monocytes, Humans, Cryoglobulinemia, Lipopolysaccharides, Tumor Necrosis Factor-alpha, RNA, Messenger, Interleukin-1, Antigen-Antibody Complex, Drug Synergism, Interferon-gamma