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The in vitro production, assay and partial characterization of an extremely potent antigen-specific T helper cell factor to poly-L-(Tyr, Glu)-poly-DL-Ala--poly-L-Lys [(T,G)-A--L] which may be an important physiological mediator of T cell function in vivo is described. The factor has an antigen-binding site, Ia and Ig-like determinants on the same molecular complex. The response to (T, G)-A--L is under H-2-linked Ir gene control, some but not all low responder haplotypes will produce the factor.

Original publication




Journal article


Eur j immunol

Publication Date





417 - 421


Animals, Binding Sites, Antibody, Cross Reactions, Dinitrobenzenes, Dose-Response Relationship, Immunologic, Epitopes, Genetic Linkage, Haploidy, Histocompatibility Antigens, Immunosorbents, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Peptides, Spleen, T-Lymphocytes