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The in vitro production, assay and partial characterization of an extremely potent antigen-specific T helper cell factor to poly-L-(Tyr, Glu)-poly-DL-Ala--poly-L-Lys [(T,G)-A--L] which may be an important physiological mediator of T cell function in vivo is described. The factor has an antigen-binding site, Ia and Ig-like determinants on the same molecular complex. The response to (T, G)-A--L is under H-2-linked Ir gene control, some but not all low responder haplotypes will produce the factor.

Original publication

DOI

10.1002/eji.1830070703

Type

Journal article

Journal

European journal of immunology

Publication Date

07/1977

Volume

7

Pages

417 - 421

Keywords

Spleen, T-Lymphocytes, Animals, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Dinitrobenzenes, Peptides, Binding Sites, Antibody, Immunosorbents, Histocompatibility Antigens, Epitopes, Cross Reactions, Dose-Response Relationship, Immunologic, Haploidy, Genetic Linkage