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Due to its ability to inhibit prometastatic matrix metalloproteinases, tissue inhibitor of metalloproteinases (TIMP)-1 has been thought to suppress tumor metastasis. However, elevated systemic levels of TIMP-1 correlate with poor prognosis in cancer patients, suggesting a metastasis-stimulating role of TIMP-1. In colorectal cancer patients, tumor as well as plasma TIMP-1 levels were correlated with synchronous liver metastasis or distant metastasis-associated disease relapse. In mice, high systemic TIMP-1 levels increased the liver susceptibility towards metastasis by triggering the formation of a premetastatic niche. This promoted hepatic metastasis independent of origin or intrinsic metastatic potential of tumor cells. High systemic TIMP-1 led to increased hepatic SDF-1 levels, which in turn promoted recruitment of neutrophils to the liver. Both inhibition of SDF-1-mediated neutrophil recruitment and systemic depletion of neutrophils reduced TIMP-1-induced increased liver susceptibility towards metastasis. This indicates a crucial functional role of neutrophils in the TIMP-1-induced premetastatic niche.Our results identify TIMP-1 as an essential promoter of hepatic premetastatic niche formation.

Original publication

DOI

10.1002/hep.27378

Type

Journal article

Journal

Hepatology (Baltimore, Md.)

Publication Date

01/2015

Volume

61

Pages

238 - 248

Addresses

Institut für Experimentelle Onkologie und Therapieforschung, Institute of Molecular Immunology Technische Universität München, München, Germany.

Keywords

Liver, Cell Line, Tumor, NIH 3T3 Cells, Animals, Mice, Inbred Strains, Humans, Mice, Carcinoma, Liver Neoplasms, Receptors, CXCR4, Tissue Inhibitor of Metalloproteinase-1, Neutrophil Infiltration, Chemokine CXCL12