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T cell activation requires interactions of T cell antigen receptors and peptides presented by major histocompatibility complex molecules in an adhesive junction between the T cell and antigen-presenting cell (APC). Stable junctions with bull's-eye supramolecular activation clusters have been defined as immunological synapses (IS). These structures maintain T cell-APC interaction and allow directed secretion. T cells can also be activated by asymmetric hemisynapses (HS) that allow migration during signal integration. IS and HS dominate in different stages of T cell priming. Optimal effector functions may also depend upon cyclical use of IS and HS.

Type

Journal article

Journal

Results and problems in cell differentiation

Publication Date

01/2006

Volume

43

Pages

175 - 198

Addresses

Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, NY 10016, USA. dustin@saturn.med.nyu.edu

Keywords

Antigen-Presenting Cells, T-Lymphocytes, Intercellular Junctions, Animals, Humans, Receptors, Antigen, T-Cell, Lymphocyte Activation, Signal Transduction, Cell Movement, Autoimmunity, Models, Immunological