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Supported planar bilayers have been used extensively in immunology to study molecular interactions at interfaces as a model for cell-cell interaction. Examples include Fc receptor-mediated adhesion and signaling and formation of the immunological synapse between T cells and antigen-presenting cells. The advantage of the supported planar bilayer system is control of the bilayer composition and the optical advantages of imaging the cell-bilayer or bilayer-bilayer interface by various types of trans-, epi- and total internal reflection illumination. Supported planar bilayers are simple to form by liposome fusion and recent advances in micro- and nanotechnology greatly extend the power of supported bilayers to address key questions in immunology and cell biology.

Original publication

DOI

10.1016/s0022-1759(03)00193-5

Type

Journal article

Journal

Journal of immunological methods

Publication Date

07/2003

Volume

278

Pages

19 - 32

Addresses

Department of Chemistry and Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA. jtgroves@lbl.gov

Keywords

Lymphocytes, Animals, Humans, Lipid Bilayers, Imaging, Three-Dimensional, Microscopy, Confocal, Cell Adhesion, Cell Communication, Models, Biological