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Naïve T cell activation requires the interactions of antigen receptors, adhesion molecules and co-stimulatory molecules. Antigen receptors and adhesion molecules are involved in spatio-temporal movement to form a stable immunological synapse. This stable junction interrupts T cell migration, and provides a platform for temporally regulated co-stimulatory receptor signaling spanning a period of days.

Original publication

DOI

10.1016/s0955-0674(02)00370-8

Type

Journal article

Journal

Current opinion in cell biology

Publication Date

10/2002

Volume

14

Pages

575 - 580

Addresses

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

Keywords

Synapses, Lymph Nodes, T-Lymphocytes, Animals, Humans, Lymphocyte Activation, Cell Adhesion, Signal Transduction, Cell Division, Cell Differentiation, Cell Movement, Time Factors