Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell-cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival.

Type

Journal article

Journal

Journal of clinical immunology

Publication Date

07/2001

Volume

21

Pages

258 - 263

Addresses

Department of Pathology, Skirball Institute of Molecular Medicine, New York University School of Medicine, New York 10016, USA. dustin@saturn.med.nyu.edu

Keywords

Antigen-Presenting Cells, T-Lymphocytes, Intercellular Junctions, Cell Adhesion Molecules, Lymphocyte Activation, Cell Communication, Signal Transduction, Cell Compartmentation, Cell Division, Cell Survival