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The stable immunological synapse between a T cell and antigen-presenting cell coordinates migration and activation. Three-dimensional collagen gels transform this interaction into a series of transient hit-and-run encounters. Here we integrate these alternative modes of interaction in a model for primary T cell activation and effector function in vivo.

Original publication

DOI

10.1016/s0952-7915(00)00217-x

Type

Journal article

Journal

Current opinion in immunology

Publication Date

06/2001

Volume

13

Pages

286 - 290

Addresses

The Molecular Pathogenesis Program, Skirball Institute of Molecular Medicine and the Department of Pathology, New York University School of Medicine, 540 First Avenue, 10016, New York, NY, USA. dustin@saturn.med.nyu.edu

Keywords

T-Lymphocytes, Extracellular Matrix, Animals, Humans, Lymphocyte Activation, Cell Movement, Organ Specificity