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The coordination of T-cell migration and antigen recognition is crucial for an effective immune response. We have proposed that this coordination is achieved by formation of an immunological synapse between the T cell and the antigen-presenting cell (APC). Our view contrasts with the serial encounter model also proposed in this issue of Trends in Immunology, which is based on transient T cell-APC interactions when surrounded by collagen. Here, we propose a model that reconciles immunological synapse formation and serial encounters based on environmental control of immunological synapse formation.

Original publication

DOI

10.1016/s1471-4906(01)01872-5

Type

Journal article

Journal

Trends in immunology

Publication Date

04/2001

Volume

22

Pages

192 - 194

Addresses

Center for Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St Louis, MO 63110, USA. dustin@saturn.med.nyu.edu

Keywords

Lymph Nodes, Antigen-Presenting Cells, T-Lymphocytes, Extracellular Matrix, Animals, Collagen, Receptors, Antigen, T-Cell, Chemokines, Lymphocyte Activation, Signal Transduction, Cell Movement, Models, Immunological, Time Factors