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The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor-ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.

Original publication

DOI

10.1126/science.285.5425.221

Type

Journal article

Journal

Science (New York, N.Y.)

Publication Date

07/1999

Volume

285

Pages

221 - 227

Addresses

Center for Immunology and the Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

Keywords

Antigen-Presenting Cells, T-Lymphocytes, CHO Cells, Animals, Mice, Transgenic, Mice, Cytochrome c Group, Lipid Bilayers, Peptides, Intercellular Adhesion Molecule-1, Receptors, Antigen, T-Cell, Antigens, CD4, Histocompatibility Antigens, Ligands, Microscopy, Interference, Lymphocyte Activation, Signal Transduction, Cell Movement, Fluorescence, Models, Immunological, Time Factors, Cricetinae