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The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

Original publication

DOI

10.1038/ni1322

Type

Journal article

Journal

Nature immunology

Publication Date

05/2006

Volume

7

Pages

517 - 523

Addresses

The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.

Keywords

Killer Cells, Natural, Cell Line, Animals, Mice, Knockout, Humans, Mice, Influenza A virus, Orthomyxoviridae Infections, Green Fluorescent Proteins, Receptors, Immunologic, Survival Rate, Species Specificity, Immunity, Innate, Natural Cytotoxicity Triggering Receptor 1