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The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.

Original publication

DOI

10.1038/ni1322

Type

Journal article

Journal

Nat immunol

Publication Date

05/2006

Volume

7

Pages

517 - 523

Keywords

Animals, Cell Line, Green Fluorescent Proteins, Humans, Immunity, Innate, Influenza A virus, Killer Cells, Natural, Mice, Mice, Knockout, Natural Cytotoxicity Triggering Receptor 1, Orthomyxoviridae Infections, Receptors, Immunologic, Species Specificity, Survival Rate